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Resveratrol Supplement (120 vegetarian capsules) High Potency with Grape Seed Extract & Quercetin easy to swallow. work quickly. gentle on the stomach

Resveratrol Supplement (120 vegetarian capsules) High Potency with Grape Seed Extract & Quercetin
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Product Description » Resveratrol Supplement (120 vegetarian capsules) High Potency with Grape Seed Extract & Quercetin

This product contains a standardized 100% natural trans form of resveratrol, which is the most bioavailable and effective source of this beneficial polyphenol. 24,000 mg trans-resveratrol per bottle. Plus the benefits of Grape Seed Extract and Quercetin!

Each capsule provides:

  • Standardized Trans-Resveratrol 200 mg (from 400 mg extract)
  • Grape Seed Extract 100 mg
  • Quercetin 100 mg

For natural synergistic support, all natural Grape Seed Extract and Quercetin have been added, both powerful sources of antioxidants found in whole red grapes.

BioSynergy Resveratrol supplement is made from the highest quality raw materials with guaranteed potency.

Supplement Facts
Serving size: 1 Vegetarian capsule
Servings Per Container: 120
One Capsule Provides: Amount Per Serving % Daily Value
Poligonum cuspidatum Extract 50% (Root)
[standardized to Trans-Resveratrol 200 mg]
400 mg *
Grape Seed Extract (Vitis vinefera)
[95% min. Proanthocyanidins]
100 mg *
Quercetin (as quercetin dihydrate 98%) 100 mg *
*Daily value not established.

Other Ingredients: magnesium stearate (vegetable source), silicon dioxide.

About other ingredients

Contains no: milk, egg, fish, peanuts, crustacean shellfish, tree nuts, wheat, yeast, gluten, corn, or sugar.

Recommended use: As a dietary supplement, take 3 capsules daily with food and water or as directed by a qualified healthcare professional.

Resveratrol Benefits:

Resveratrol, a naturally occurring phytoalexine found mainly in Japanese Knotweed (Polygonum cuspidatum) and red grape skins, has been associated with a wide range of health benefits.

Researchers are focused on enzymes called sirtuins that are activated by resveratrol. When activated, sirtuins have been shown to invigorate mitochondria. A sirtuin known as SIR2 strengthens the cell’s mitochondria keeping them young and vital. Activated SIR2 has been shown in laboratory studies to increase the health, vitality, and lifespan in every organism it has been tested on so far, from aging yeast to rats and mice. Activated SIR2 induced mitochondria have been shown to not only increase lifespan by 30% but include all the other good things you see when mitochondria is working properly like: abundant energy, improved memory, improved heart function, cellular health, healthy joint function, and the list goes on.

In animal and lab studies, Resveratrol has been demonstrated to:

  • Improve healthy artery function by multiple mechanisms. 1
  • Help protect liver from over consumption of alcohol. 2
  • Improves endothelial function in overweight men and women at dosages of 30, 90 or 270 mg resveratrol over 4 weekly intervals. 3
  • Open arteries by enhancing nitric oxide. 4
  • Inhibit the growth of toxic breast cells. 10
  • Activate longevity gene extending healthy lifespan.
  • Protect against degenerative diseases of aging. 64
  • Significantly increase physical endurance by as much as 100%.
  • Reduce heart rate and energy-charge muscles during exercise.
  • Increase number of energy generating mitochondria in muscle cells.
  • Improve mitochondrial function.
  • Protect from negative metabolic effects of a high fat diet.
  • Provide the same health benefits of caloric restriction. 64
  • Increase activity of healthy enzymes called sirtuins.
  • Scavenge harmful free radicals preventing free radical damage.
  • Stop proliferation of cells in blood vessels that narrow the arteries. 5
  • Keep blood cells from sticking together. 6
  • Help protect healthy heart function. 15
  • Protect the brain against oxidative stress, keeping cells alive.
  • Block or stop many stages of abnormal cell growth. 7,8,9
  • Stop growth of unhealthy cell proliferation. 11,12,13,14
  • Prevent unhealthy cell growth in lungs. 16
  • Promote and maintain healthy inflammation response.
  • Protect immune cells.
  • Protect DNA and mitochondria against alcohol’s toxic effects. 58,59,60
  • Activates SIRT1 which switches off production of many unhealthy inflammation response cytokines that contribute to unhealthy cell growth. 61,62

Resveratrol Supplement Improves Glucose Levels

Published in the Journal of Gerontology: Biological Studies, researchers at Albert Einstein College of Medicine found a benefit for resveratrol supplementation in men and women with impaired glucose tolerance.

Ten overweight subjects aged 65 and older who had elevated fasting and two hour glucose levels participated in the study. Participants took either 1.0, 1.5. or 2 grams of resveratrol per day for four weeks.

For all participants, fasting glucose levels remained unchanged after four weeks but peak post-meal glucose levels decreased by an average of 19 mg/dL and three hour glucose levels also declined. Additionally, participants’ insulin sensitivity improved and had better post-meal endothelial function.

J Gerontol A Biol Sci Med Sci. 2012 Jan 4

A wealth of new research findings continue to support the potential of resveratrol, a powerful antioxidant that has been shown to significantly impact the aging process.

Resveratrol Supplement Reduces Weight Gain

In a primate study published online in the journal BMC Physiology, researchers found that taking a resveratrol supplement reduces seasonal body-mass gain.* Supplementing with resveratrol for four weeks reduced the animals’ seasonal weight gain by decreasing calorie intake by 13% and increasing resting metabolic rate by 29%.

“The physiological benefits of resveratrol are currently under intensive investigation, with recent work suggesting that it could be a good candidate for the development of obesity therapies,” said Dr. Aujard, researcher at the Centre Nutritional de la Scientifique in France.

*http://www.biomedcentral.com/1472-6793/10/11/abstract. Accessed Sep 6, 2010

Quercetin

The super antioxidant Quercetin, one of the strongest biologically active members of the flavonoid family, is found in grapes, yellow and red onions, and some other fruits and vegetables. Like Resveratrol and Grape Seed Extract, studies with Quercetin are numerous and ongoing.

In animal and lab studies, Quercetin has been demonstrated to:

  • Protect white blood cells from environmental toxins.
  • Destroy dangerous free radicals superoxide and peroxide.
  • Protect brain cells from free radical damage.
  • Protect the liver against toxic exposure caused by industrial chemicals in the environment.
  • Inhibit type of enzyme that HIV uses to replicate.
  • Strengthen immune system.
  • Block biochemicals that contribute to dermatitis.
  • Inhibit release of histamines helping to combat allergies such as hay fever.
  • Help maintain mental performance under conditions of extreme physical stress.
  • Help support and maintain a healthy inflammation response. 27,28,32,33,38
  • Have anti-allergic effects, acting as a natural antihistamine. 27,34,35
  • Be a most promising compound for disease prevention and therapy. 31
  • Promote longevity by mimicking the effects of caloric restriction. 29,30
  • Dramatically reduce reactions to chemicals that trigger asthma attacks. 36,37
  • Reduce replication and infectivity of numerous viruses. 27
  • Help protect mice against illness following exercise induced stress. 39
  • Suppress new fat cells and destroy existing fat cells in human fat cell culture. 40,41
  • Block the uptake of glucose into fat cells from the blood. 42
  • Decrease fat accumulation by 70% and fat apoptosis when combined with resveratrol. 43
  • Help support and maintain artery health. 44
  • Support healthy endothelial function by augmenting nitric oxide (NO) status. 45
  • Help support and maintain healthy blood and arteries. 28
  • Supress unhealthy cell proliferation while promoting healthy DNA. 46-52
  • Increase resistance to oxidative stress, prolonging the life span of laboratory yeast cells in culcture by 60%. 29
  • Improve overall health and longevity by activating specific genes. 53,54
  • Mimic many beneficial biological effects of caloric restriction which extends lifespan in animals and possibly humans. 30,55,56
  • Promote and maintain healthy brain function through reduction in free radical damage. 57

Grape Seed Extract

The health promoting biologically active components of grape seeds are called Oligomeric Proanthocyanidins, Proanthocyanidins, or OPC’s. The grape seed extract used in BioSynergy’s resveratrol formula contains a minimum of 95% with typical assay at 99.99% proanthocyanidins. Proanthocyanidins are bioflavonoids that perform as free radical scavengers in the body. Grape Seed Extract’s powerful antioxidant activity is 15 to 20 times stronger than that of Vitamin E and 50 times stronger than that of Vitamin C.

In animal and lab studies, Grape Seed Extract has been demonstrated to:

  • Support capillary strength.
  • Reduce DNA fragmentation in the brain and liver by 50% after exposure to a harmful chemical.
  • Reduce a type of protein that impedes the brain’s ability to make new cells.
  • Increase and normalize beneficial proteins in the brain that are diminished with age.
  • Promote healthy glucose response and mobilize fat by strengthening metabolism.
  • Reverse some skin damage caused by the sun.
  • Promote and maintain healthy bones.
  • Promote and maintain healthy teeth.
  • Prevent alcohol-induced oxidative damage in all tissues examined in animal studies. 58,63
  • Block unhealthy cell proliferation in the colon. 17
  • Improve and maintain normal healthy blood by 43% in men and women. 18
  • Reduce markers of oxidative stress that are associated with unhealthy artery function. 19
  • Support and maintain normal healthy blood pressure levels. 20,23,26
  • Fight advanced glycation end product (AGE) formation, an early step in producing an unhealthy inflammation response. 21,22
  • Promote and maintain healthy heart function. 24
  • Promote and maintain normal healthy brain function. 25

Resveratrol Research:

Resveratrol Mimics Calorie Restriction’s Effects

A recent article in Cell Metabolism indicates that men supplementing with resveratrol experienced metabolic effects similar to those observed in animal studies of calorie restriction.

After 30 days of taking 150 mg a day of trans-resveratrol, metabolic measures for body mass index, whole-body energy expenditure, liquid storage, plasma markers of metabolic function, and other values were measured and compared to pre-study measurements.

“We demonstrate beneficial effects of resveratrol supplementation for 30 days on the metabolic profile in healthy obese males which seems to reflect effects observed during calorie restriction.” The authors write.

Cell Metab. 2011 Nov 2:14(5):612-22

December, 2006

Resveratrol found to counter effects of obesity also aids endurance

NEW YORK TIMES

Resveratrol, already shown to reverse the effects of obesity in mice and make them live longer has now been shown to increase their endurance, as well.

Experts say the finding may open a new field of research on similar substances that may be relevant to the prevention of illness. An ordinary lab mouse will run 1 kilometer on a treadmill before collapsing from exhaustion. But mice given resveratrol, a compound of Japanese Knotweed(polygonum cuspidatum), and red wine, run twice as far. They also have a reduced heart rate and energy-charged muscles, just as trained athletes do according to an article published by Johan Auwerx and colleagues at the Institute of Genetics and Molecular and Cellular Biology in Illkirch, France.

He and his colleagues said the same mechanism seems likely to operate in humans, based on their analysis of a group of Finnish subjects of the gene that is influenced by resveratrol.

Their rationale for testing resveratrol was evidence obtained three years ago that it could trigger a genetic mechanism known to protect mice against the degenerative diseases of aging and prolong their lifespan.

Auwerx, whose interest is in the genetic control of metabolism, decided to see if resveratrol would offset the effects of a high-fat diet. In his report, he and his colleagues say very large doses of resveratrol protected mice from gaining weight and developing metabolic syndrome.

Auwerx attributes this chance in large part to the significantly increased number of mitochondria he detected in the muscle cells of treated mice.

Mitochondria are the organelles within the body’s cells that generate energy. With extra mitochondria, the treated mice were able to burn off more fat and thus avoid weight gain and decreased sensitivity to insulin, Auwerx said.

Ronald M. Evans, a leading expert on the hormonal control of metabolism at the Salk Institute, said the report by Auwerx’s team had “shown very convincingly that resveratrol improves mitochondrial function”. He described the study as “very important, because it is rare that we identify orally active molecules, especially natural molecules, that have such a broad-based, positive effect.”

Auwerx’s study compliments one published earlier this month by David Sinclair of the Harvard Medical School, who found that much more moderate doses protected mice from the metabolic effects of a high-calorie diet. Though his mice did not lose weight, they lived far longer than the undosed mice fed the same high-calorie diet.

A natural substance that prolongs life, averts degenerative disease and on top of all that makes one into a champion athlete, at least if one is a mouse, sounds almost too good to be true, especially if all or even some of its properties should turn out to apply to people.

Sinclair has been swallowing resveratrol capsules for three years, and has said his parents and half the members of his lab do the same. So does Thomas Prolla at the University of Wisconsin. “The fact that investigators in the field are taking it is a good sign there is something there,” he said.

November, 2006

Resveratrol may help you lose weight… Study also shows resveratrol may promote longer life

THE WASHINGTON POST

A substance found in grape skins and Japanese Knotweed (polygonum cuspidatum) protected mice from the ill effects of obesity, raising the tantalizing prospects the compound could do the same for humans and may also help people live longer, healthier lives, researchers reported.

The substance, called resveratrol, enabled mice that were fed a high-calorie, high-fat diet to live normal, active lives despite becoming obese – the first time any compound has been shown to do that. Tests found the agent activated a host of genes that protect against the effects of aging, essentially neutralizing the adverse effects of a bad diet on the animals’ health and lifespan.

Although much more work is needed to explore the benefits and safety of the substance, which is sold over the counter as a nutritional supplement, the findings could lead to the long-sought goal of extending the healthy human lifespan, experts said. Preliminary tests in people are already underway. “We’ve been looking for something like this for the last 100,000 years, and maybe it’s right around the corner – a molecule that could be taken in a single pill to delay the diseases of aging and keep you healthier as you grow old,” said David A. Sinclair, a Harvard University molecular biologist who led the study. “The potential impact would be huge.”

The findings triggered excitement among scientists studying aging, who hailed the findings as groundbreaking. “This represents a likely major landmark,” said Stephen Helfand, who studies the molecular genetics of aging at Brown University. “This really pushes the field forward. It’s quite exciting.”

The research, being published in today’s issue of the journal Nature, helps explain a host of observations that have long intrigued researchers, including why French people tend to get fewer heart attacks and why severely restricting the amount of calories animals ingest makes them live longer.

“This gives us hope that the idea of harnessing the power of calorie restriction is not a fantasy and can be brought to reality,” said Leonard Guarente, who studies the biology of aging at the Massachusetts Institute of Technology. “This could produce a whole new approach to preventing and treating the diseases of aging.” Previous research has shown that laboratory animals fed very low-calorie diets live significantly longer, which has prompted some people to strenuous “caloric restriction” diets as a possible fountain of youth, even though its effectiveness in humans remains unproven.

In the hope of finding a drug that could harness the natural life-extending capabilities activated by caloric restriction, Sinclair and his colleagues identified a number of the promising compounds, including resveratrol. Resveratrol, which increases the activity of enzymes known as sirtuins, prolonged the lifespan of every organism scientists have tested it on, including yeast, worms, fish and fruit flies.

The researchers cautioned that the findings should not encourage people to eat badly, thinking resveratrol could make gluttony completely safe. They also noted that a person would have to drink at least 100 bottles of red wine a day (average of 3 mg per bottle) or take mega doses of the commercially available supplements to get the levels given to the mice.

But the findings indicate that resveratrol or molecules like it could have myriad benefits, and several aging researchers said the results tempted them to start using the supplements in the meantime.

“I’m usually a very cautious person,” said Cynthia Kenyon of the University of California in San Francisco. “But I’m seriously thinking about taking resveratrol myself.”

Resveratrol Supplement Side Effects:

At this time there are no clinically proven side effects with Resveratol Supplement when used appropriately. If you are taking any prescribed drugs from your physician, please check the Drug Interactions before taking this nutritional supplement.

Resveratrol Supplement Dosage:

Recommended use: As a dietary supplement, take 3 capsules daily with food and water or as directed by a qualified healthcare professional.

Refrences

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*The above statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

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Product Reviews » Resveratrol Supplement (120 vegetarian capsules) High Potency with Grape Seed Extract & Quercetin

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