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Acetyl-l-Carnitine 500 mg & R-Alpha Lipoic Acid 100 mg Vegetarian Combo Pack – Save Money! easy to swallow. work quickly. gentle on the stomach

Acetyl-l-Carnitine 500 mg & R-Alpha Lipoic Acid 100 mg Vegetarian Combo Pack  – Save Money!
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Product Description » Acetyl-l-Carnitine 500 mg & R-Alpha Lipoic Acid 100 mg Vegetarian Combo Pack – Save Money!

Pharmaceutical grade – Vegetarian - Get complete information below:

  • 1 Bottle: R-Alpha Lipoic Acid Pharmaceutical grade R-form ALA 100 mg (120 vegetarian capsules)
  • 1 Bottle: Acetyl-L-Carnitine Pharmaceutical Grade Biosint™ 500 mg (120 vegetarian capsules)

Suggested usage: Take 2 – 3 capsules of each daily.

BioSynergy Acetyl-l-carnitine & R-Alpha Lipoic Acid supplements are made from the highest quality raw materials with guarateed potency

Supplement Facts
Serving size: 1 Vegetarian Capsule
Servings Per Container: 120
One Capsule Provides: Amount Per Serving % Daily Value
Biotin 100 mcg 33%
R-Alpha Lipoic Acid  100 mg *
*Daily value not established.

Other Ingredients: Cellulose, Stearic Acid (vegetable source), and Silicon Dioxide.

About other ingredients

Contains no: yeast, dairy, egg, gluten, corn, wheat, sugar, fragrance, and preservatives.

Supplement Facts
Serving size: 1 Vegetarian Capsule
Servings Per Container: 120
One Vegetarian Capsule Provides: Amount Per Serving % Daily Value
Acetyl-l-carnitine HCL (Biosint™) 500 mg *
*Daily value not established.

Other Ingredients: Cellulose and Silicon Dioxide.

About other ingredients

Contains no: yeast, dairy, egg, gluten, corn, wheat, sugar, fragrance, and preservatives.

Biosint™ is a trademark of Sigma-tau HealthSciences.

Acetyl-l-Carnitine and Alpha Lipoic Acid Benefits:

Dietary Supplements Make Old Rats Youthful, May Help Rejuvenate Aging Humans, According To UC Berkeley Study
Source: University Of California – Berkeley (http://www.berkeley.edu/) Date: Posted 2/19/2002

Berkeley - Two dietary supplements, straight off the health food store shelf put the spark back into aging rats, and might do the same for aging baby boomers, according to a study at the University of California, Berkeley, and Children’s Hospital Oakland Research Institute. A team of researchers led by Bruce N. Ames, professor of molecular and cell biology at UC Berkeley, fed older rats two chemicals normally found in the body’s cells and available as dietary supplements: acetyl-L-carnitine and an antioxidant, alpha-lipoic acid.

In three articles in the February 19 issue of Proceedings of the National Academy of Sciences, Ames and his colleagues report the surprising results. Not only did the older rats do better on memory tests, they had more pep, and the energy-producing organelles in their cells worked better.

“With the two supplements (acetyl-l-carnitine and alpha lipoic acid) together, these old rats got up and did the Macarena,” said Ames, also a researcher at Children’s Hospital Oakland Research Institute (CHORI).

“The brain looks better, they are full of energy – everything we looked at looks more like a young animal.”

“The animals seem to have much more vigor and are much more active than animals not on this diet, signaling massive improvement to these animals’ health and well-being,” said former UC Berkeley post-doctoral fellow Tory M. Hagen, now an assistant professor at the Linus Pauling Institute at Oregon State University, Corvallis. “And we also see a reversal in loss of memory. That is a dual-track improvement that is significant and unique. This is really starting to explode and move out of the realm of basic research into people.”

One of the three PNAS articles probes the reasons behind this rejuvenation, concluding that the two chemicals “tune up” the energy-producing organelles that power all cells, the mitochondria. Both chemicals are normally used in mitochondria.

Ames calls mitochondria the “weak link in aging.” Evidence has been piling up, he said, that deterioration of mitochondria is an important cause of aging. A significant cause of this deterioration, he believes, is the accumulation of destructive free radicals – byproducts of normal metabolism – that disable enzymes and other chemicals.

The combination therapy targets mitochondria to get rid of destructive radicals and to boost the activity of a damaged enzyme, carnitine acetyltransferase, that plays a key role in burning fuel in mitochondria. The researchers hoped that the anti-oxidant alpha-lipoic acid would do the former, and that flooding the cell with acetyl-L-carnitine, one of two proteins that the enzyme acts on, would achieve the latter.

Experiments showed that this regimen worked. Associate researcher Jiankang Liu of CHORI, UC Berkeley postdoctoral fellow David W. Killilea and Ames demonstrated that the enzyme carnitine acetyltransferase is less active in old rats than in young rats, and that it binds less tightly to acetyl-L-carnitine in older rats.

Supplementation with acetyl-L-carnitine or a combination of acetyl-L-carnitine and alpha-lipoic acid restored the enzyme’s activity nearly to that found in young rats and substantially restored binding to acetyl-L-carnitine.

“The acetyl-L-carnitine is protecting the protein and the higher levels are enabling the protein to work, while alpha-lipoic acid knocks down oxygen radicals,” Ames said. “Each chemical solves a different problem – the two together are better than either one alone.”

Ames and Hagen have long had an interest in mitochondria as they relate to aging, and they were intrigued by a 1999 Italian study that showed acetyl-L-carnitine, when fed to old rats, improved mitochondrial activity.

The two thought this might be a way to reverse the effects of aging on mitochondria, and in various trials found it to work to some degree. Free radicals were still damaging the cell, however, so they decided to pair it with one of the few antioxidants that gets into mitochondria, alpha-lipoic acid. Lipoic acid is produced by mitochondria and boosts levels of other antioxidants.

In the second of the PNAS studies, Hagen, Ames and colleagues compared 2- to 4-month-old rats to 24- to 28-month-old rats, all fed acetyl-L-carnitine in their water and alpha-lipoic acid in their chow.

After as much as a month on the supplements, the old and lethargic rats became more peppy, Ames said.

“We significantly reversed the decline in overall activity typical of aged rats to what you see in a middle-aged to young adult rat 7 to 10 months of age,” Hagen said. “This is equivalent to making a 75- to 80-year-old person act middle-aged. We’ve only shown short-term effects, but the results give us the rationale for looking at these things long term.”

They found also that the combination of lipoic acid and acetyl-carnitine improved mitochondrial activity and thus cellular metabolism, and increased levels of various chemicals known to decline with age, including ascorbic acid, an antioxidant.

In a third study, Liu, Hagen, Ames and colleagues fed old rats a similar diet of the two supplements and looked at memory function as measured by the Morris water maze test and a peak procedure for assessing temporal or time-based memory developed by Seth Roberts, professor of psychology at UC Berkeley. They found that supplementation improved both spatial and temporal memory, and reduced the amount of oxidative damage to RNA in the brain’s hippocampus, an area important in memory. In electron microscope pictures of cells from the hippocampus, mitochondria showed less structural decay in old rats that had a supplemented diet.

“We did two different tests for cognitive activity in rats, and in both it made a big difference to feed them this mixture,” Ames said. “Memory degenerates with age, and this makes them better.”

The analysis of nucleic acid damage in the brain was performed with post-doctoral researcher Elizabeth Head and Carl W. Cotman, professor of neurobiology and behavior, at the Institute for Brain Aging and Dementia at UC Irvine. UC Berkeley psychology graduate student Afshin M. Gharib worked with Liu to conduct the peak performance tests.

“In aging, you’re oxidizing the proteins in mitochondria and they lose activity,” Ames explained. “If some of that lost activity is due to binding for substrate or coenzyme – like binding of acetyl-L-carnitine by carnitine acetyltransferase – and you can raise the level of those, then you can reverse some of the loss.

“We showed, in fact, that that is what’s happening with acetyl-L-carnitine. Aldehydes from lipid oxidation are glomming onto that protein, and that is what appears to cause the reduction in binding activity. But if you raise the level of acetyl-L-carnitine, now it works.”

Hagen added, “With aging, we see so many different things that are occurring to mitochondria that then lead to consequences in the cell. If you tune up mitochondria you may have a means of at least delaying the onset of a number of age-related problems that we encounter, or we can in some ways, hopefully, reverse what has already taken place.”

The work was supported by grants from the Ellison Foundation, the National Institute on Aging of the National Institutes of Health, the Wheeler Fund of the Dean of Biology at UC Berkeley, the Bruce and Giovanna Ames Foundation and the National Institute of Environmental Health Sciences Center at UC Berkeley.

R-Alpha Lipoic Acid

BioSynergy’s pure natural R-Alpha Lipoic Acid (R-ALA), and active isomer of Lipoic Acid, is easily synthesized and metabolized by the body. R-ALA is 2 times more effective than regular (RS) Alpha Lipoic Acid and is a key component of mitochondrial dehydrogenase, which may help to slow the natural aging process in animals. Alpha lipoic acid is known as the “universal antioxidant” because of its unique solubility in both water and fat. It has the ability to conserve and prolong the life of vitamins C & E in the body, increasing their effectiveness. Alpha lipoic acid is also an excellent metal detoxifier, particularly for mercury and cadmium, which it binds to and neutralizes for excretion.

Alpha Lipoic Acid serves as a coenzyme in the energy production process in the cells which can provide quick bursts of energy. Alpha Lipoic Acid is unique in that it is both water and fat soluble which allows it to enter all parts of the cell to neutralize free radicals. Alpha Lipoic Acid contributes to invigorating mental and physical energy and a reduction in muscle fatigue. Dr. Lester Packer, a leading researcher in the area of antioxidants and a professor of molecular and cell biology at the University of California at Berkeley says “Alpha-Lipoic acid could have far-reaching consequences in the search for prevention and therapy of chronic degenerative diseases such as diabetes and cardiovascular disease” …. “and because it’s the only antioxidant that can easily get into the brain, it could be useful in preventing damage from a stroke”.

Common uses for supplemental alpha Lipoic Acid:

  • May play a role in controlling blood sugar.
  • Important for the production of energy inside the cell by utilizing sugar to produce energy contributing to mental and physical stamina.
  • Neutralizes free radicals. Unlike Vitamin C which is water soluble and Vitamin E which is fat soluble, alpha Lipoic Acid is both water and fat soluble which allows it to enter all parts of the cell to neutralize free radicals.
  • May help reduce LDL (bad) blood cholesterol.
  • May help improve memory.
  • Chelates (grabs) heavy metals and binds them reducing these oxidants from blood system.
  • Inhibits Glycation which is responsible for accelerated tissue damage.
  • Recycles and enhances the effects of other antioxidants such as Vitamin E and Vitamin C.
  • Significantly increase survival in rats that have suffered a stroke if given before the stroke occurs.
  • Not only does it act as an antioxidant itself, it also stimulates production of glutathione (an antioxidant produced by the body), giving cells a double dose of antioxidant.
  • Easily absorbed when taken orally and once inside cells is quickly converted to its most potent form, dihydrolipoic acid.
  • Because both alpha lipoic acid and dihydrolipoic acid are antioxidants, their combined actions give them greater antioxidant potency than any natural antioxidant now known.
  • Important for regulating aspects of the immune system, in particular immune cells called T-lymphocytes.
  • Researchers believe ALA treatment improves endothelium-dependent vasodilation in patients with type 2 diabetes.1
  • Alpha Lipoic Acid reduced triglycerides in obese and diabetic rats.2
  • Migraine sufferers may be able to reduce the frequency and severity of their headaches by supplementing with lipoic acid.3

1. Alpha Lipoic Acid(ALA) treatment on endothelium-depennts vasodilation in patients with type 2 diabetes. Eur J Clin Invest. 2010;40(2):148-54
2. Arch Biochem Biophys. 2009 Feb 20
3. Magis D, Ambrosini A, Sandor P, Jacquy J, Laloux P, Schoenen J. A randomized double-blind placebo-conrolled trial of thioctic acid in migraine prophylaxis. Headache 2007 Jan:47(1):57-2

Acetyl-l-carnitine

Acetyl-l-carnitine is a stabilized form of the amino acid metabolite L-Carnitine and is utilized in the same manner in the body. Acetyl-l-carnitine plays an important role in the transfer and utilization of long-chain fatty acids, which are used in the production of energy.

BiosintTM pharmaceutical grade Acetyl-L-Carnitine is manufactured in Italy by Sigma Tau Health Sciences which is the premier international clinical research organization for ALC and its uses.

NOTE: Beware of internet brands that claim “pharmaceutical grade acetyl-l-carnitine” but don’t include name of manufacturer. There are only two manufacturers in the world who make pharmaceutical grade acetyl-l-carnitine. They are Sigma Tau Health Sciences (Biosint™) and Lonza (L-Carnipure™). Non-brand ALC is made in China and much less expensive.

Acetyl-l-carnitine is a molecule that occurs naturally in the brain, liver, and kidney. Natural levels of Acetyl-l-carnitine diminish as we age.

Common uses for supplemental Acetyl-l-carnitine:

  • To enhance cognition.
  • Involved in the metabolism of food into energy.
  • Mild mental impairment in the elderly showed a significant improvement of several performances during and after Acetyl-l-carnitine treatment.
  • Reports indicate that Acetyl-l-carnitine may be effective in the treatment of dementia.
  • Treated Down syndrome patients showed statistically significant improvements of visual memory and attention both in absolute terms and in comparison with the other groups.
  • To significantly improve items measuring quality of life.
  • Improve both spatial and temporal memory, and reduce the amount of oxidative damage to RNA in the brain’s hippocampus, an area important in memory.
  • Acetyl-l-carnitine is widely used as an energy supplement in Italy.
  • Can dramatically improve mitochondrial function and protect the mitochondria from damage.
  • A review of clinical studies shows that ALC may slow the natural course of Alzheimer’s disease.1
  • In combination with alpha lipoic acid, ALC helps maintain heart muscle function in aging animals.2
  • L-carnitine improves embryo quality and increases blastocyst development rate in couples undergoing ICSI3
  • Brain

The acetyl group that is part of acetyl-L-carnitine contributes to the production of the neurotransmitter acetylcholine, which is required for mental function.

More Acetyl-l-Carnitine and Alpha Lipoic Acid Benefits & Info:

Carnitine Supplement Helps Sperm Swim

By David Douglas

NEW YORK (Reuters Health) – Taking carnitine supplements seems to improve sperm mobility in men with poorly active sperm, a problem known as asthenozoospermia, Italian researchers report.

However, for carnitine to work, tiny structures within the cell called mitochondria must function properly. Mitochondria are important because they provide the energy needed for sperm to move their tail and “swim.”

Senior investigator Dr. Carlo Foresta told Reuters Health that “it is well known that in some asthenozoospermic subjects an improvement of sperm (motion occurs) after carnitine administration…However in other asthenozoospermic patients this effect is not present.”

To investigate further, Foresta of the University of Padua and colleagues studied 30 asthenozoospermic men divided into two groups depending on whether they had normal or abnormal mitochondria function. The researchers’ findings appear in the medical journal Fertility & Sterility.

In patients with normal mitochondria function, movement rose from 29.3 percent before treatment to 41.1 percent after 3 months of carnitine. However, in those with abnormal function, movement held steady at about 24 percent.

Thus, Foresta concluded that carnitine treatment is useful “in ameliorating sperm motility only when optimal…mitochondrial function … is conserved.”

SOURCE: Fertility & Sterility 2005.

Q. What is the difference between L-Carnitine and Acetyl-L-Carnitine?

A. L-Carnitine and Acetyl-L-Carnitine have overlapping health benefits especially with regard to producing energy in the mitochondria in organs and muscle tissue throughout the body.

The main difference is that L-Carnitine is found in higher concentrations in muscle tissue including the heart so the emphasis is on producing physical energy whereas Acetyl-L-Carnitine is found in concentrations in the brain so the emphasis is on providing healthy brain function.

Q. Can both forms of Carnitines be taken at the same time?

A. It is safe to take both forms of Carnitines at the same time using the suggested daily usage of either one split between the two.

1. Carta A, Calvani M. Acetyl-l-carnitine: able to show the progress of Alzheimer’s disease? Ann NY Acad Sci. 1991;640:228-32
2. Hagen TM, Moreau R, Suh JH, Visioli F. Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acety-l-carnitine and/or alpha lipoic acid. Ann NY Acad Sci. 2002 Apr;959:491-507
3. Fertility and Sterility Volume 90, Supplement 1, September 2008

Acetyl-l-Carnitine and Alpha Lipoic Acid Side Effects:

Are there any drug interactions? A. Didanosine (Depletion or interference) Didanosine is a drug that blocks reproduction of the human immunodeficiency virus (HIV). HIV is the virus that infects people causing acquired immunodeficiency syndrome (AIDS). Didanosine is used in combination with other drugs to treat HIV infection.

If you are taking any prescribed drugs from your physician, please check the Drug Interactions before taking this nutritional supplement.

Acetyl-l-Carnitine and Alpha Lipoic Acid Dosage:

Suggested usage: Take 2 – 3 capsules of each daily.

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*The above statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Product Guarantee » Acetyl-l-Carnitine 500 mg & R-Alpha Lipoic Acid 100 mg Vegetarian Combo Pack – Save Money!

All BioSynergy products are made with only the highest purity all natural raw materials in a GMP cerified facility. If for any reason you are not satisfied with a BioSynergy product, simply return the unused portion within 30 days of purchase for a full refund. No Questions asked.

Product Reviews » Acetyl-l-Carnitine 500 mg & R-Alpha Lipoic Acid 100 mg Vegetarian Combo Pack – Save Money!

2 Responses to “Acetyl-l-Carnitine 500 mg & R-Alpha Lipoic Acid 100 mg Vegetarian Combo Pack – Save Money!”

  1. I.C. USA says:
    • 55555

    “This is my second order of these two products and I am very pleased with the results I am beginning to see after 6 weeks of usage.”

  2. Robert Ellis says:
    • 55555

    “I am 79 and I don’t have alzheimer’s so it must be good.”

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