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Promote Mental Focus, Strength & More!
Individual cases of cognitive decline can range from bothersome to devastating in their effects on quality of life.
One of the best ingredients on the market for reducing cognitive dysfunction is alpha-glyceryl phosphoryl choline (A-GPC). A-GPC has been studied for its potential benefits in many aspects of brain wellness.
BioSynergy Alpha-GPC supplement is made from the highest quality raw materials with guarateed potency.
| Supplement Facts Serving size: 1 vegetarian capsule Servings Per Container: 60 |
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| One Capsule Provides: | Amount Per Serving | % Daily Value |
| Alpha-GPC (Alpha-Glycerylphosphorylcholine) 50% | 600 mg | * |
| *Daily value not established. |
Other ingredients: Cellulose, Stearic Acid (vegetable source), and Silicon Dioxide.
Contains no: yeast, wheat, gluten, corn, milk, egg, sugar or salt.
Suggested Usage: As a dietary supplement, take one capsule 1 to 2 times daily with or between meals. Consider taking this product in combination with BioSynergy Neuro Clear.
Medline summary:
Alpha-GPC or GPC has been documented extensively by published studies in both animals and humans to contribute to at least five (5) significant human health functions.
These relevant ‘mind-body’ activities include, but may not be limited to the following:
1. Increases human Growth Hormone (hGH)
Increases in endogenous human Growth Hormone (hGH) secretion by the anterior pituitary in conjunction with Growth Hormone Releasing Hormone (GHRH); that is, both Alpha-GPC and GHRH act concertedly to stimulate the release of hGH, naturally;
2. Improved mental focus and stimulation of cognitive function
Stimulation of the enzymatic synthesis of phosphatidylcholine (PC) in nerves, muscle cells and all cell membranes, counteracting the age-related decrease in phospholipid (PC) biosynthesis; thus, Alpha-GPC contributes directly to improved mental focus and stimulation of cognitive function;
3. More strength from work-outs and training programs
Acts as a precursor of acetylcholine (ACh); thus, Alpha-GPC activates cholinergic transmission which permits the development of more strength from work-outs and training programs, plus reducing levels of somatostatin in the hypothalamic-pituitary axis;
4. Improved lipotrophic functions in the liver
Elevations in blood and tissue levels of the essential nutrient, choline, which supports improved lipotrophic functions (methyl group transferases) in the liver. Research has shown that fatty liver, a condition associated with obesity, diabetes and heavy alcohol consumption, often leads to cirrhosis of the liver or liver failure. Studies conducted by Alan L. Buchman, M.D., associate professor of medicine at The Feinberg School of Medicine at Northwestern University, have shown that fatty liver can be prevented and possibly even eliminated with increased levels of choline. Alpha-GPC also acts synergistically with the body’s store (and/or supplementation) of S-adenosyl-L-methionine (SAM or SAMe) and folic acid, vitamin B12 and vitamin B6 to facilitate methyl group transfers in the brain and liver;
5. Improved balanced and coordination
Produces improved balanced and coordination when combined with ‘skill set’ practice and training as a result of normalized nerve transmission in the brain, and in cardiac, skeletal and smooth muscles.
Alpha-GPC has been shown to potentiate the effects of growth hormone releasing hormone (GHRH) and increase human growth hormone (hGH) secretion in young and elderly individuals. Alpha-GPC also affects numerous biochemical and neurotransmitter systems that have been implicated in the development of age-related memory dysfunction (ARMD).
Administration of Alpha-GPC has been shown to improve neuropsychological parameters in patients with SDAT and ARMD. Alpha-GPC also improves memory and cognitive performance. Alpha-GPC has been shown to reduce the recovery time in comatose patients suffering from head injury and antagonize the effects of scopolamine to improve memory, attention, and performance in healthy individuals. Alpha-GPC’s cognitive and growth hormone (GH) enhancing effects appear to be primarily the result of stimulation of the cholinergic neurotransmitter system; however, other biochemically-related modulations and neurotransmitter systems have been implicated.
Alpha-GPC improves memory, attention, and performance in healthy individuals. Alpha-GPC’s cognitive and growth hormone (GH) enhancing effects appear to be primarily the result of stimulation of the cholinergic neurotransmitter system; however, other biochemically-related modulations and neurotransmitter systems have been implicated.
Aging and prolonged stress – including athletic endeavors like marathons or ‘ironman/ironwoman’ events are associated with decreased hormone production, especially reduced secretion of human Growth Hormone (hGH) from the anterior pituitary. These life events are also associated with lower levels of free choline in the blood and tissues. Concomitantly, both quality of life and lifespan decrease, sexual desire and potency diminish, muscles loose both protein (mass) and tone, and body fat levels increase.
In clinical situations, significantly reduced secretion of hGH is associated with short stature, generalized muscle wasting, andropause, anxiety, undesirable mood and affect changes which are often associated with depression, abnormal sleep patterns, loss of energy and stamina, and decreased cellular and humoral (antibody) immune functions leading to increased susceptibility to disease.
Fate and distribution studies demonstrate that orally administered Alpha-GPC is absorbed quickly from the gastrointestinal tract and is transported in the blood to all cells and tissues, especially the brain. Alpha-GPC crosses the ‘blood-brain’ barrier and acts as a central nervous system (CNS) cholinergic stimulant while it simultaneously increases the GHRH-stimulated secretion of hGH by the somatotrophe cells in the anterior pituitary. The current understanding of Alpha-GPC’s actions in the brain is that it increases hGH secretion in the pituitary by two (2) separate but interacting neuro-endocrine mechanisms; these are:
1. Modulatory – increasing cholinergic tone lending to decreased levels of somatostatin (produced by the hypothalamus), as a result of the administration of Alpha-GPC;
2. Regulatory – stimulation of hGH synthesis resulting from ‘up regulation’ of Growth Hormone Releasing Hormone/Factor (GHRH/GHRF) in conjunction with receptor-linked stimulation of the adenylate cyclase (cAMP)-Protein kinase C (PKC)-inositol triphosphate (IP3) intracellular control mechanisms regulating hGH synthesis at the genomic level and its subsequent secretion by the anterior pituitary.
Alpha-GPC has been administered to over three thousand (3,000) patients and volunteers in clinical trials and studies that have been published in the peer-reviewed literature. Minor, transient side effects have been reported to occur at a one percent (1%) frequency; these side effects, for orally administered Alpha-GPC, included diarrhea, dizziness, gastralgis, heartburn, insomnia, restlessness and skin rashes, which resolved when the amount of Alpha-GPC administered was either decreased or eliminated.
Alpha-GPC in the mental recovery of brain injury.
Institute of Internal Medicine and Geriatrics, University of Palermo, Italy.
The clinical efficacy and the tolerability of alpha-glycerophosphocholine (alpha-GPC), a natural plant extract able to provide high levels of choline for the nervous cells of the brain and to protect their cell walls, have been tested in a clinical open multicenter trial on 2044 patients suffering from recent disrupted bloodflow induced brain injury. Alpha-GPC was administered after the attack at the daily dose of 1000 mg im for 28 days and orally at the dose of 400 mg tid during the following 5 months after the first phase. The evaluation of the efficacy on the psychic recovery was done by the Mathew Scale (MS) during the period of im drug administration, and using the Mini Mental State Test (MMST), the Crichton Rating Scale (CRS), and the Global Deterioration Scale (GDS) during the following period of oral administration. The MS mean increased 15.9 points in 28 days in a statistically significant way (p < 0.001) from 58.7 to 74.6. At the end of the 5 month oral administration, the CRS mean significantly decreased 4.3 points, from 20.2 to 15.9 (p < 0.001); the MMST mean significantly increased (p < 0.001) from 21 to 24.3 at the end of the trial, reaching the “normality” score at the 3rd month assessment. The GDS score at the end of the trial corresponded to “no cognitive decline” or “forgetfulness” in 71% of the patients. Adverse events were complained of by 44 patients (2.14%); in 14 (0.7%) the investigator preferred to discontinue therapy. The most frequent complaints were heartburn (0.7%), nausea-vomit (0.5%), insomnia-excitation (0.4%), and headache (0.2%). The trial confirms the therapeutic role of alpha-GPC on the cognitive recovery of patients with disrupted bloodflow induced brain injury, and the low percentage of adverse events confirms its excellent tolerability.(ann ny acad sci 1994 June)
At this time there are no clinically proven side effects with Alpha-GPC when used appropriately. If you are taking any prescribed drugs from your physician, please check the Drug Interactions before taking this nutritional supplement.
As a dietary supplement, take one capsule 1 to 2 times daily with or between meals. Consider taking this product in combination with BioSynergy Neuro Clear and Bio-G.
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*The above statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
All BioSynergy products are made with only the highest purity all natural raw materials in a GMP cerified facility. If for any reason you are not satisfied with a BioSynergy product, simply return the unused portion within 30 days of purchase for a full refund. No Questions asked.
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