New and Improved
This product contains a standardized 100% natural trans form of resveratrol, which is the most bioavailable and effective source of this beneficial polyphenol. 1,200 mg trans-resveratrol per bottle. Plus the benefits of Red Wine Extract!
Each capsule provides:
For natural synergistic support, all natural Red Wine Extract has been added,a powerful source of antioxidants found in whole red grapes.
BioSynergy Resveratrol supplement is made from the highest quality raw materials with guaranteed potency.
Serving size: 1 Vegetarian capsule
Servings Per Container: 60
|One Capsule Provides:||Amount Per Serving||% Daily Value|
|Poligonum cuspidatum Extract 50% (Root)
[standardized to Trans-Resveratrol 200 mg]
|Red Wine Extract (alcohol free)
[Vitas vinifera](fruit)(standardized for polyphenols)
|*Daily value not established.|
Other Ingredients: magnesium stearate (vegetable source), silicon dioxide.
Contains no: milk, egg, fish, peanuts, crustacean shellfish, tree nuts, wheat, yeast, gluten, corn, or sugar.
Recommended use: As a dietary supplement, take 1 capsule daily with food and water or as directed by a qualified healthcare professional.
Resveratrol, a naturally occurring phytoalexine found mainly in Japanese Knotweed (Polygonum cuspidatum) and red grape skins, has been associated with a wide range of health benefits.
Researchers are focused on enzymes called sirtuins that are activated by resveratrol. When activated, sirtuins have been shown to invigorate mitochondria. A sirtuin known as SIR2 strengthens the cell’s mitochondria keeping them young and vital. Activated SIR2 has been shown in laboratory studies to increase the health, vitality, and lifespan in every organism it has been tested on so far, from aging yeast to rats and mice. Activated SIR2 induced mitochondria have been shown to not only increase lifespan by 30% but include all the other good things you see when mitochondria is working properly like: abundant energy, improved memory, improved heart function, cellular health, healthy joint function, and the list goes on.
In animal and lab studies, Resveratrol has been demonstrated to:
Resveratrol Supplement Improves Glucose Levels
Published in the Journal of Gerontology: Biological Studies, researchers at Albert Einstein College of Medicine found a benefit for resveratrol supplementation in men and women with impaired glucose tolerance.
Ten overweight subjects aged 65 and older who had elevated fasting and two hour glucose levels participated in the study. Participants took either 1.0, 1.5. or 2 grams of resveratrol per day for four weeks.
For all participants, fasting glucose levels remained unchanged after four weeks but peak post-meal glucose levels decreased by an average of 19 mg/dL and three hour glucose levels also declined. Additionally, participants’ insulin sensitivity improved and had better post-meal endothelial function.
J Gerontol A Biol Sci Med Sci. 2012 Jan 4
A wealth of new research findings continue to support the potential of resveratrol, a powerful antioxidant that has been shown to significantly impact the aging process.
Resveratrol Supplement Reduces Weight Gain
In a primate study published online in the journal BMC Physiology, researchers found that taking a resveratrol supplement reduces seasonal body-mass gain.* Supplementing with resveratrol for four weeks reduced the animals’ seasonal weight gain by decreasing calorie intake by 13% and increasing resting metabolic rate by 29%.
“The physiological benefits of resveratrol are currently under intensive investigation, with recent work suggesting that it could be a good candidate for the development of obesity therapies,” said Dr. Aujard, researcher at the Centre Nutritional de la Scientifique in France.
*http://www.biomedcentral.com/1472-6793/10/11/abstract. Accessed Sep 6, 2010
Resveratrol Mimics Calorie Restriction’s Effects
A recent article in Cell Metabolism indicates that men supplementing with resveratrol experienced metabolic effects similar to those observed in animal studies of calorie restriction.
After 30 days of taking 150 mg a day of trans-resveratrol, metabolic measures for body mass index, whole-body energy expenditure, liquid storage, plasma markers of metabolic function, and other values were measured and compared to pre-study measurements.
“We demonstrate beneficial effects of resveratrol supplementation for 30 days on the metabolic profile in healthy obese males which seems to reflect effects observed during calorie restriction.” The authors write.
Cell Metab. 2011 Nov 2:14(5):612-22
Resveratrol found to counter effects of obesity also aids endurance
NEW YORK TIMES
Resveratrol, already shown to reverse the effects of obesity in mice and make them live longer has now been shown to increase their endurance, as well.
Experts say the finding may open a new field of research on similar substances that may be relevant to the prevention of illness. An ordinary lab mouse will run 1 kilometer on a treadmill before collapsing from exhaustion. But mice given resveratrol, a compound of Japanese Knotweed(polygonum cuspidatum), and red wine, run twice as far. They also have a reduced heart rate and energy-charged muscles, just as trained athletes do according to an article published by Johan Auwerx and colleagues at the Institute of Genetics and Molecular and Cellular Biology in Illkirch, France.
He and his colleagues said the same mechanism seems likely to operate in humans, based on their analysis of a group of Finnish subjects of the gene that is influenced by resveratrol.
Their rationale for testing resveratrol was evidence obtained three years ago that it could trigger a genetic mechanism known to protect mice against the degenerative diseases of aging and prolong their lifespan.
Auwerx, whose interest is in the genetic control of metabolism, decided to see if resveratrol would offset the effects of a high-fat diet. In his report, he and his colleagues say very large doses of resveratrol protected mice from gaining weight and developing metabolic syndrome.
Auwerx attributes this chance in large part to the significantly increased number of mitochondria he detected in the muscle cells of treated mice.
Mitochondria are the organelles within the body’s cells that generate energy. With extra mitochondria, the treated mice were able to burn off more fat and thus avoid weight gain and decreased sensitivity to insulin, Auwerx said.
Ronald M. Evans, a leading expert on the hormonal control of metabolism at the Salk Institute, said the report by Auwerx’s team had “shown very convincingly that resveratrol improves mitochondrial function”. He described the study as “very important, because it is rare that we identify orally active molecules, especially natural molecules, that have such a broad-based, positive effect.”
Auwerx’s study compliments one published earlier this month by David Sinclair of the Harvard Medical School, who found that much more moderate doses protected mice from the metabolic effects of a high-calorie diet. Though his mice did not lose weight, they lived far longer than the undosed mice fed the same high-calorie diet.
A natural substance that prolongs life, averts degenerative disease and on top of all that makes one into a champion athlete, at least if one is a mouse, sounds almost too good to be true, especially if all or even some of its properties should turn out to apply to people.
Sinclair has been swallowing resveratrol capsules for three years, and has said his parents and half the members of his lab do the same. So does Thomas Prolla at the University of Wisconsin. “The fact that investigators in the field are taking it is a good sign there is something there,” he said.
Resveratrol may help you lose weight… Study also shows resveratrol may promote longer life
THE WASHINGTON POST
A substance found in grape skins and Japanese Knotweed (polygonum cuspidatum) protected mice from the ill effects of obesity, raising the tantalizing prospects the compound could do the same for humans and may also help people live longer, healthier lives, researchers reported.
The substance, called resveratrol, enabled mice that were fed a high-calorie, high-fat diet to live normal, active lives despite becoming obese – the first time any compound has been shown to do that. Tests found the agent activated a host of genes that protect against the effects of aging, essentially neutralizing the adverse effects of a bad diet on the animals’ health and lifespan.
Although much more work is needed to explore the benefits and safety of the substance, which is sold over the counter as a nutritional supplement, the findings could lead to the long-sought goal of extending the healthy human lifespan, experts said. Preliminary tests in people are already underway. “We’ve been looking for something like this for the last 100,000 years, and maybe it’s right around the corner – a molecule that could be taken in a single pill to delay the diseases of aging and keep you healthier as you grow old,” said David A. Sinclair, a Harvard University molecular biologist who led the study. “The potential impact would be huge.”
The findings triggered excitement among scientists studying aging, who hailed the findings as groundbreaking. “This represents a likely major landmark,” said Stephen Helfand, who studies the molecular genetics of aging at Brown University. “This really pushes the field forward. It’s quite exciting.”
The research, being published in today’s issue of the journal Nature, helps explain a host of observations that have long intrigued researchers, including why French people tend to get fewer heart attacks and why severely restricting the amount of calories animals ingest makes them live longer.
“This gives us hope that the idea of harnessing the power of calorie restriction is not a fantasy and can be brought to reality,” said Leonard Guarente, who studies the biology of aging at the Massachusetts Institute of Technology. “This could produce a whole new approach to preventing and treating the diseases of aging.” Previous research has shown that laboratory animals fed very low-calorie diets live significantly longer, which has prompted some people to strenuous “caloric restriction” diets as a possible fountain of youth, even though its effectiveness in humans remains unproven.
In the hope of finding a drug that could harness the natural life-extending capabilities activated by caloric restriction, Sinclair and his colleagues identified a number of the promising compounds, including resveratrol. Resveratrol, which increases the activity of enzymes known as sirtuins, prolonged the lifespan of every organism scientists have tested it on, including yeast, worms, fish and fruit flies.
The researchers cautioned that the findings should not encourage people to eat badly, thinking resveratrol could make gluttony completely safe. They also noted that a person would have to drink at least 100 bottles of red wine a day (average of 3 mg per bottle) or take mega doses of the commercially available supplements to get the levels given to the mice.
But the findings indicate that resveratrol or molecules like it could have myriad benefits, and several aging researchers said the results tempted them to start using the supplements in the meantime.
“I’m usually a very cautious person,” said Cynthia Kenyon of the University of California in San Francisco. “But I’m seriously thinking about taking resveratrol myself.”
Resveratrol Supplement Side Effects:
At this time there are no clinically proven side effects with Resveratol Supplement when used appropriately. If you are taking any prescribed drugs from your physician, please check the Drug Interactions before taking this nutritional supplement.
Recommended use: As a dietary supplement, take 1 capsule daily with food and water or as directed by a qualified healthcare professional.
1. Fan E, Zhanf, I, Jiang S, Bai Y,. Beneficial effects of resveratrol on atherosclerosis J Med Food 2008 Dec 11:4;610-4
2. Ajmo JM, Liang X, Roger CQ, Pennock B, You M. Resveratrol alleviates fatty liver in mice. Am J Physiol. Gastrointest Liver Physiol. 2008 Oct;259(4):G833-42
3. Nutr Metab Cardiovasc Dis. 2010 Jul 29
4. Zou JG, et al. Effect of red wine and wine polyphenols resveratrol on endothelial function in hypercholesterolemia rabbits.
5. Haider UG, et al. Resveratrol increases serine 15-phosphorylated but transcriptionally impaired p53 and induces a reversible DNA replication block in serum-activated vascular smooth muscle cells. Mol Pharmacol. 200;363:925-32
6. Zbikowska HM, et al. Antioxidants with carcinostatic activity(resveratrol, vitamin E, ad selenium) in modulation of blood platelet adhesion. J Physiol Pharmacol. 2000;51:513-20
7. Cal C, et al. Resveratrol and cancer; chemoprevention, apoptis, and chemoimmunosensitizing activities. Curr Med Chem Anti-Cancer Agents. 2003;3:77-93
8. Pervais S. Resveratrol-from the bottle to bedside? Leuk Lymphoma. 2001;40:491-8
9. Ding XY, et al. Resveratrol inhibits proliferation and induces apoptis in human pancreatic cancer cells. Pancreas 2002;25:e71-e76
10. Nakagawa H, et al. Resveratrol inhibits human breast cencer cell growth and may mitigate the effect of linoleum acid, a potent breast cancer cell stimulator. J Cancer Res Clin Oncol. 2001;127:258-64
11. Benitez DA, et al. Mechanisms involved in resveratrol-induced apoptis and cell cycle arrest in prostate cancer-derived cell lines. J of Andrology. 2006 Oct 18
12. Riles WL, et al. Resveratrol engages selective apoptic signals in gastric adenocaecinoma cell. World J of Gastoenterology. 2006 Sep 21
13. Sareen D, et al. Mitochondria as the primary target of resveratrol-induced apoptic in human retinoblastoma cells. Investigative Ophthamol and Vis Science. 2006 Sep.
14. Farber AC, Chiles TC. Resveratrol induces apoptosis in transformed follicular lymphoma OCI-LY8 cells: Evidence for a novel mechanism involving inhibition of BCL6 signaling. Int. J of Oncology. 2006 Dec.
15. Ray PS, Maulik G, Cardis GA, et al. The red wine antioxidant resveratrol protects isolated rat hearts from ischema reper fusion injury. Free Rad Biol Med. 1999;27:160-169
16. Kimura Y, Okuda H. Resveratrol isolated from polygonum cuspidatum root prevents tumor growth and metastasis to lung and tumor-induced neovascularization in Lewis lung carcinoma-bearing mice. J. Nutr. 2001 Jan;131(6):1844-9
17. Kuar M, Singh RP, Gu M, Agarwal R, Agarwal C. Grape seed extract inhibits in vitro and in vivo growth of human colorectal carcinoma cells. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6194-202
18. Cancer Epidemio Biomarkers Prev. 2011 Aug 23
19. Sano A, Uchida R, Saito M, et al. Beneficial effects of grape seed extract on malondialdehyde-modified LDL. J Nutr Sci Vitamin (Tokyo). 2007 Apr;53(2):174-82
20. Badavi M, Mehrgerdi FZ, Sarkaki A, Maseri MK, Dianat M. Effect of grape seed extract on lead induced hypertention and heart rate in rat. Pak J Biol Sci. 2008Mar 15:11(6):882-7
21. Li X, Xiao Y, Gao H, et al. Grape seed Proanthocyanidins ameliorate diabetic nephropathy via modulation of levels of AGE, RACE, and CTGF. Nephron Exp Nephrol. 2009; 111(2):231-41
22. Sick E, Brehin S, Andre P, et al. Advanced glycation and products (AGEs) activate most cells. Br J Pharmacol. 2010 Sep; 161(2):442-55
23. Li X, Xu L, Gao H, Li B, Cheng M. Effects of grape seed Proanthocyanidins extracts on AGEs and expression of bone morphogenetic protein-7 in diabetic rats. J Nephrol. 2008 Sep-Oct;21(5):722-33
24. Pataki T, Bak I, Kovacs P, Bagchi D, Das DK, Tosaki A. Grape seed Proanthocyanidins improved cardiac recovery during reperfusion after ischemia in isolated rat hearts. Am J Clin Nutr. 2002 May:75(5):894-9
25. Carlson S, Peng N, Prasain JK, Wyss JM. Effects of botamical dietary supplements on cardiovascular; cognitive; and metabolic function in males and females. Gend Med. 2008;Suppl A:S76-90
26. Sivaprakasapillai B, Edirisinghe I, Randolf J, Steinberg F, Kappagoda T. Effect of grape seed extract on blood pressure in subjects with metabolic syndrome. Metabolism. 2009 Dec;58(12):1743-6
27. No authors listed. Quercetin. Monograph. Altern Med Rev. 1998 Apr;3(2):140-3
28. Rivera L, Moron R, Sanchez M, Zarzuelo A, Galisteo M. Quercetin ameliorates metabolic syndrom and improves the inflammatory status in obese zucker rats. Obesity(Silver Spring). @008 Sep;16(9):2081-7
29. Belinha I, Amorim MA, Rodriquez P, et al. Quercetin increases oxidative stress resistance and longevity in Saccharomyces cerevisiae. J Agric Food Chem. 2007 Mar 21;55(6):2446-51
30. Barger JL, Kavo T, Pugh TD, Prolla TA, Weindruch R. Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart. Exp Gerontol. 2008 Sep;43(9):859-66
31. Bischoff Sc. Quercetin: potentials in prevention and therapy of disease. Curr-Opin Clin Nutr Metab Care. 2008 Nov;11(6):733-40
32. Min YD, Choi CH, Bark H, et al. Quercetin inhibits expression of inflammatory cytokins through attentuation of NF-kappaB and p38 MARK in HMC-1 human mast cell line. Inflamm Res. 200 May;56(5):210-5
33. Warren CA, Paulhill KJ, Davidson LA, et al. Quercetin may suppress rat aberrant crypt toci formation by suppressing inflammatory mediators that influence proliferation and apoptis. J Nutr. 2009 Jan;131(1):101-5
34. Cruz EA, Da-Silva SA, Muzitano MF, et al. Immunodulatory pretreatment with Kalancho pinnata extract and its Quercetin flavonoid effectively protects mice against fatal anaphylactic shock. Int Immunopharmacol. 2008 dec. 10;8(12):1616-21
35. Park HJ, Lee CM, Jung ID, et al. Quercetin regulates Th1/Th2 balance in murine model of asthma. Int Immunopharmacol. 2008 Dec 2.
36. Jiang JS, Chien HC, Chen CM, Lin CN, Ko WC. Potent suppressive effects of 3-0-methylquercetin on ovalbumin-induced airways hyper responsiveness. Planta Med. 2007 Sep;73(11):1156-62
37. Jung Ch, Lee JY, Cho CH, Kim CJ. Anti-asthatic actions of Quercetin and rutin on guinea-pigs challenged with aerosolized ovalbumin. Arch Pharm Res. 2007 Dec;30(12):599-607
38. Chun OK, Chung SJ, Clavcombe KJ, Song WD. Serum C-reactive protein concentrations are inversely associated with dietary flavanoids intake in U.S. adults. J Nutr. 2008;138(4):753-60
39. Davis JM, Murphy EA, McClellan JL, Carmichael MD, Gangemi JD. Quercetin reduces susceptibility to influenza infection following stressful exercise. Am J Physiol Regul Integr Comp Physiol. 2008 Aug;295(2):R505-9
40. Ahn J, Lee H, Kim S, Park J, Ha, T. The anti-obesity effect of Quercetin is mediated by the AMPK and MARK signaling pathways. Biochem Biophys Res Com. 2008 Sep;5:37(4)545-9
41. Park HJ, Yang JY, Ambati S, et al. Combined effects of genistein, Quercetin and resveratrol in human and 3T3-L1 adiposities. J Med Food 2008 Dec;11(4):773-83
42. Strobel P, Allard C, Perez-Acle T, et al. Myricetin, Quercetin and catechins-qullate inhibit glucose uptake in isolated rat adiposities Biochem J. 2005 Mar;15:386(pt 3):471-8
43. Yang JL, La-Fera MA, Ravalam S, et al. Enhanced inhibition of adiposeness and induction of apoptosis in 3T3-L1 adiposities with combinations of resveratrol and Quercetin. Life Sci. 2008 May 7;82(19-20):1032-9
44. Hubbard GP, Walfram S, Lovegrove JA, Gibbins JM. Ingestion of Quercetin inhibits platelet agrigation and essential components of the collagen-stimulated platelet activation pathway in humans. J Thromb Haemost. 2004 Dec;2012:2138-45
45. Luke WM, Hodgson JM, Proudfoot JM, et al. Pure dietary flavanoids Quercetin and epicatechin augment nutric oxide producs and reduce endothelia-1 acutely in healthy men. Am J Clin Nutr. 2008 Oct;88(4):1018-25
46. Choi EJ, Bae SM, Ahn WS. Antiproliferative effects of Quercetin through cell cycle arrest and apoptosis in human breast cancer MDAMB-453 cells. Arch Pharm Res. 2008 Oct;31(10):1281-5
47. Bayle Sp, Dobson VL, Duthie SJ, Kyle JA, Collins AR. Absorption and DNA protective effects of flavanoids glycosides from an onion meal. Eur J Nutr. 2000 Oct;39(5):213-23
48. Seigelin MD, Reuss DE, Habel A, Rami A, Von DA. Quercetin promotes degredation of surviving and thereby enhances death receptor mediated apoptis in glioma cells. Neuro Oncol. 2008 Oct 29
49. Tan S, Wang C, Lu C, et al. Quercetin is able to demethelate the p161NK4a gene promoter. Chemotherapy. 2009;55(1):6-10
50. Vasquez-Garzon VR, Rellanes-Robledo J, Garcia-Roman R, Parrisio-Bantista DI, Villa-Travino S. Inhibition of reactive oxygen species and pre-neoplastic lesions by Quercetin through an antioxidant defense mechanism. Free Radic Res. 2008 Dec;29:1-10
51. Warren CA, Pawlhill KJ, Davidson LA, et al. Quercetin may suppress rat aberrant crypt foci formation by suppressing inflammatory medication that influence proliferation and apoptis. J Nutr. 2009 Jan;139(1):101-5
52. Cruz-Correa M, Shoskes DA, Sanches P,, et al. Combination treatment with curcumin and Quercetin of adenomas in familial adenomatous polyposis. Clin Gastroenterol Hepatol. 2006 Aug;4(8):1035-8
53. Pietsch K, Saul N, Menzel R, Sturzenbaum SR, Steinberg CE. Quercetin mediated lifespan extension in Caenorhabditis elagans is modulated by age-1, dat-2, sek-1 and unc-43. Biogerontology. 2008 Nov 29
54. Saul N, Pietsch K, Menzel R, Steinberg CE. Quercetin medicated longevity in Caenorhabditis elegans: is DAF-16 involved? Mech Aging Dev. 2008 Oct;129(10):611-3
55. Martin CK, Anton SD, Han H, et al. Examination of cognitive function during six months of caloric restriction; results of a randomized controlled trial. Rejuvenation Res. 2007 Jun;10(2):179-90
56. Ghosh HS. The anti-aging, metabolism potential of SIRT1. Curr Opin Investig Drugs. 2008 Oct;9(10):1095-102
57. Ansari MA, Abdul HM, Joshi G, Opii WO, Butterfield DA. Protective effect of Quercetin in primary neurons against Abeta(1042): relevance to Alzheimer’s disease. J Nutr Biochem. 2008 Jul 3
58. Gui L, Wang LH, Sun B, et al. Dires in vivo evidence of protective effects of grape seed procyanidin fractions and other antioxidants against ethanol-induced oxidative DNA damage in mouse brain cells. J Agric Food Chem 2007 Jul 11;55(4):5881-91
59. Manzo-Avelos S, Saavedra-Molina A. Cellular and mitochondrial effects of alcohol consumption. Int J Environ Res Public Health. 2010 Dec;7(12):4281-304
60. Yan Y, Yang J, Chen G, et al. Protection of resveratrol and its analogues against ethanol-induced oxidative DNA damage in human peripheral lymphocytes. Mutat Res. 2011 Apr 3;72(2):171-7
61. Agarwal B, Baur JA. Resveratrol and life extension. Ann NY Acad Sci. 2011 Jan;1215:138-43
62. Shen Z, Ajimo JM, Rogers CQ, et al. Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF-alpha production in cultured macrophage cell lines. Am J Physiol Gastrointest Liver Physiol. 2009 May;296(5):G1047-53
63. El-Ashmawy IM, Saleh A, Salama DM. Effects of marjoram volatile oil and grape seed extract on ethanol toxicity in male rats. Basic Clin Pharmacol Toxicol. 2007 Nov:101(5):320-7′
64. Person KJ, Baur JA, Lewis KN, et al. Resveratrol delays age related deteriorization and mimic transcriptional aspects of dietary restriction without extending life span. Cell Metab 2008 Jul 2
Scroll up to add this High Potency Resveratol to your cart!
*The above statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
All BioSynergy products are made with only the highest purity all natural raw materials in a GMP cerified facility. If for any reason you are not satisfied with a BioSynergy product, simply return the unused portion within 30 days of purchase for a full refund. No Questions asked.